What is the link between your genetics and Parkinson's?1
The exact cause of Parkinson’s is unknown, but research points to a combination of environmental and genetic factors. Your genes contain instructions that tell your cells to make molecules called proteins, which perform various functions in your body to keep you healthy. Each gene carries instructions that determine your features, such as eye color and height.
In some cases, Parkinson’s appears to be associated with a single gene mutation in the DNA of affected individuals. Some of the most common mutations may include mutations in the LRRK2, GBA, and SNCA genes. These gene mutations potentially change the role that specific proteins play in normal functioning and therefore may influence the risk for developing Parkinson’s.
The more we learn about genetics and Parkinson’s, the more we will be able to understand the causes of the disease and develop new therapies that target these gene mutations to treat Parkinson's. Denali’s current investigational treatment is looking specifically at the connection between LRRK2 and Parkinson’s.